Recursos académicos, investigaciones y materiales de referencia actualizados, diseñados para fortalecer la práctica médica y el aprendizaje continuo.
Radiotherapy Prescription Dose and Normal Tissue Tolerance Dose Protocol Version 2.0, November 2022 Compiled by Dr. Balaji K, PhD Sr. Medical Physicist Gleneagles Global Hospitals, Chennai
A National Audit of Current UK Practice on the Use of Anti-Emetics for Chemotherapy-Induced Nausea and Vomiting in Children.
Radiotherapy Volume Relationships (Platy Graph).
Palliative Medicine and Hospice Care for Physician Associates.
Intensive chemotherapy for high-risk acute lymphoblastic leukemia in first remission: results from the NOPHO ALL2008 study.
PedROC 2.0: provider confidence in Wilms tumor management in sub-Saharan Africa: making the case for pediatric radiotherapy inclusion during basic medical training.
A Decade of Transformation in the Management of Childhood Acute Lymphoblastic Leukemia: From Conventional Chemotherapy to Precision Medicine.
AIEOP-BFM ALL 2017 International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia.
Management of pediatric brain tumors in low- and middle-income countries.
Three decades of radiotherapy advancements for pediatric ependymoma.
Translational advancement of immunotherapeutics against pediatric central nervous system tumors.
Current advances in the management of atypical teratoid rhabdoid tumors (ATRT).
Non-germinomatous germ cell tumors of the CNS: Classification, diagnosis, and treatment.
Medulloblastoma chapter - past perspectives and future directions.
Emerging interventional treatments in the management of pediatric brain tumors.
Germinoma: Presentation, Management, and Recent Advances.
The precise definition of target volumes in radiotherapy represents one of the most critical steps in radiation treatment planning, directly impacting treatment efficacy and patient safety. The International Commission on Radiation Units and Measurements (ICRU) has established standardized terminology and protocols through a series of reports (ICRU 50, 62, 71, and 83) to ensure consistency across radiotherapy centers worldwide.
The palliative care team has been asked to see a 5-year-old boy in the pediatric intensive care unit (PICU) with hypoxic ischemic encephalopathy secondary to a drowning episode 3 years ago. The child is ventilation-dependent, and this is the fifth admission for recurrent pneumonia this year. The family has been very clear about their goals of care but do not feel supported by the medical team
As a leading organization in radiation oncology, the American Society for Radiation Oncology (ASTRO) is dedicated to improving quality of care and patient outcomes. A cornerstone of this goal is the development and dissemination of clinical practice guidelines based on systematic methods to evaluate and classify evidence, combined with a focus on patient-centric care and shared decision-making. ASTRO develops and publishes guidelines without
La Leucemia Linfoblástica Aguda (LLA) es el tipo de cáncer más común en la infancia, representa el 75% de los casos de leucemia en niños, niñas y adolescentes 1. Constituye un problema relevante de salud pública debido a su alta incidencia.
Recent developments in radiation and neuro-oncology provide the ability to deliver required radiation dose to target volumes for pediatric brain tumors while avoiding sensitive normal central nervous system (CNS) structures uninvolved by tumor. Many CNS target volumes are smaller than in previous years due to better understanding of areas at risk for recurrence or involvement and patterns of spread for a given diagnoses. Advances in neuroimaging and treatment planning software allow for better delineation of tumors and normal neuroanatomy
NCCN Guidelines Version 1.2026 Prostate Cancer
Lattice Radiation Therapy (LRT) is an innovative radiotherapy (RT) technique that allows to concurrently administering ablative doses inside neoplastic lesions and low doses near the adjacent organs at risks (OARs) (See Fig. 1). LRT can be considered as a type of spatially fractionated radiation therapy (SFRT) and it represents the 3-dimensional (3D) configuration of the 2-dimensional (2D) GRID therapy (See Fig. 2) [1]. The heterogeneous dose distribution of a LRT plans entails the creation of a 3D array inside the planning target volume (PTV), where high-dose (vertices or hotspots) and low-dose areas (periphery
While COG and Euronet use three risk groups (low, intermediate, and high), the authors chose to dichotomize groups as most included articles categorized patients as limited or advanced disease. Low- and intermediate-risk (IR) diseases in studies describing three risk groups were analyzed within the limited disease group. Each study had their own criteria for risk stratification. Two sets of bias assessments were conducted, using methodologies used by the Pediatric Normal Tissue Effects in Clinic
The consensus was discussed during monthly webbased national meetings, and the algorithms were revised until a consensus was achieved. Results: A total of 26 participants were involved in the development of the algorithms. Two treatment algorithms are proposed, one for the initiation of treatment and one for the discontinuation of treatment.
Background: Prostate cancer (PCa) is the most common malignant tumor in men in Mexico. There are two treatments with curative potential, such as radical prostatectomy (RP) for localized disease and radical radiotherapy (R-RT). Control rates are determined by the prognostic factors present. Objective: The objective of this study was to determine the control and survival rate with radical conformal radiotherapy (R-CR) in PCa. Methods: The 8.5-year results of an institutional series are presented using Cox proportional hazards analysis and Kaplan-Meier survival.
Childhood cancer is prevalent throughout the world.1 With modern technologies and therapies, high-income countries (HICs) now report cure rates as high as 80% for children with cancer.2,3 However, low- and middle-income countries (LMICs) struggle with lack of health care resources and infrastructure, resulting in upward of 90% of pediatric oncologic deaths occurring in these countries.2-4 As radiotherapy is a critical component of care for children with malignancies, improving quality and access to pediatric radiotherapy services in LMICs is vital.5 Ethiopia is a low-income country (LIC) in sub-Saharan Africa with a multitude of distinct ethnic groups, languages, and religions
El cáncer es la tercera causa de muerte en México con más de 91,500 fallecimientos anuales. Uno de cada dos pacientes requiere radioterapia como parte de su tratamiento, pero nuestro país cuenta con apenas 2 equipos por millón de habitantes, cuando la recomendación internacional es de 4. Esto coloca a México en desventaja incluso frente a países de ingresos bajos.
Introduction: Post-treatment surveillance is recommended for NSCLC owing to a high risk of recurrence, but evidence on the optimal surveillance method is lacking. This trial evaluates fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) versus contrast-enhanced CT (ceCT) for surveillance in patients with NSCLC.
Antecedentes: La irradiación cráneo-espinal (ICE) tiene un impacto decisivo en el control de tumores pediátricos con alta probabilidad de diseminación por líquido cefalorraquídeo, pero se asocia a defectos del desarrollo de la columna vertebral en etapa de crecimiento. Objetivo: Analizar las alteraciones de columna posteriores a ICE, y la comparación dosimétrica de las técnicas de radioterapia conformada (RC) y arco volumétrico de intensidad modulada (VMAT).
Precision oncology has transformed the management of NSCLC by tailoring treatment to the specific genetic alterations driving oncogenesis. Targeted therapies, such as tyrosine kinase inhibitors, have been found to dramatically improve survival in patients with advanced-stage NSCLC.
Summary Background In postmenopausal women with oestrogen receptor-positive early breast cancer, 5 years of adjuvant tamoxifen substantially reduces 15-year recurrence and mortality; aromatase inhibitor treatment (AIT) is even more effective. We assess the effects of further AIT among women recurrence-free after at least 5 years of endocrine therapy
AstraZeneca. He received travel support from the Radiosurgery Society. He is member of the data safety monitoring board or advisory board for Genentech, ViewRay, AstraZeneca, and Roche. He holds leadership or fiduciary roles in the Radiosurgery Society and ASTRO. Ben J. Slotman is president of the Radiosurgery Society.
a Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; b Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio; c Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; d Department of Radiation Oncology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; e Department of Radiation Oncology, Stanford University, Stanford, California; and f Department of Radiation Oncology, University of California San Francisco, San Diego, California
Purpose: Plasma Epstein−Barr virus (EBV) DNA is a widely used biomarker for nasopharyngeal carcinoma (NPC). Prior investigations predominantly assessed EBV DNA at a single time point, thus neglecting the differential prognostic implications of the temporal clearance pattern of EBV DNA during induction-concurrent (chemo)radiation therapy (RT).
Corresponding author: Matthew Poppe, MD; E-mail: matthew. poppe@hci.utah.edu This protocol is registered with ClinicalTrials.gov and may be viewed online at https://clinicaltrials.gov/study/NCT03345420 Author Responsible for Statistical Analysis: Kenneth Boucher, PhD. Disclosures: M.M.P. is an investor in PEEL Therapeutics, Inc., and K.E. B. serves as a consultant for Impedimed. M.M.P. also reports the following roles and associations: Vice Chair, Breast Committee, Alliance; Co-Chair, Breast Locoregional Working Group, Alliance; Member, Executive Committee and Board of Directors, Alliance; Member,
Background: The clinical significance of multi-kingdom skin microbiota in acute radiation dermatitis (ARD) is not well understood. We hypothesized that skin microbiota is associated with ARD in patients with breast cancer (BC) undergoing radiation therapy (RT) after reconstructive surgery
Guía para el manejo del dolor en pequeños procedimientos en pediatría. Dirigida a profesionales. DIRECCIÓN Y COORDINACIÓN Pilar Hilarión Subdirectora. Instituto Universitario Avedis Donabedian - Universitat Autònoma de Barcelona. Red de investigación en servicios de salud en enfermedades crónicas (REDISSEC) Carola Orrego Subdirectora. Instituto Universitario Avedis Donabedian - Universitat Autònoma de Barcelona. Red de investigación en servicios de salud en enfermedades crónicas (REDISSEC) Área Social de la Fundación Bancaria “la Caixa”.
The definitive management of many pediatric malignancies requires radiation therapy (RT) to the central nervous system (CNS) that may predispose survivors to neurologic complications. A detailed understanding of radiation dosevolume effects is required to maximize the therapeutic ratio of brain irradiation.
Treatment protocols for childhood cancer have changed rapidly over the years, maintaining a balance between effective therapy and acceptable toxicity.
As cancer survival rates continue to improve, longterm adverse effects of treatment on health and quality of life are increasingly important considerations for clinicians, patients, and familymembers. Neurocognitive deficits (NCD) are well established as a common adverse effect in brain tumor survivors, owing to the tumor itself, but also localized brain irradiation treatment.
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Abstract: Radiation therapy, a common treatment for central nervous system cancers, can negatively impact cognitive function, resulting in radiation-induced cognitive decline (RICD). RICD involves a decline in cognitive abilities such as memory and attention, likely due to damage to brain white matter, inflammation, and oxidative stress
Simple Summary: Radiation therapy-related brain damage with neurocognitive impairment is a common long-term side effect in cancer survivors and significantly impairs the quality of life. Increasing evidence indicates the increased vulnerability of the developing brain to the neurotoxic effects of ionizing radiation (IR).
Abstract: The brain undergoes ionizing radiation (IR) exposure in many clinical situations, particularly during radiotherapy for malignant brain tumors. Cranial radiation therapy is related with the hazard of long-term neurocognitive decline.
FAST-Forward Boost A randomised clinical trial testing a 1-week schedule of curative simultaneous integrated boost radiotherapy against a standard 3-week schedule in patients with early breast cancer.
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EAU - EANM - ESTRO - ESUR - ISUP - SIOG Guidelines on Prostate Cancer
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CONSENSO MEXICANO SOBRE DIAGNÓSTICO Y TRATAMIENTO DEL CÁNCER MAMARIO UNDÉCIMA REVISIÓN, ENERO 2025. RADIOONCOLOGÍA: Dra. Adela Poitevín Chacón Radiooncóloga Médica Sur, Ciudad de México. Dra. Christian Haydeé Flores Balcázar Radiooncóloga Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, SS., Ciudad de México.
TNM Classification of Malignant Tumours 9th Edition Edited by: James Brierley, Meredith Giuliani, Brian O'Sullivan, Brian Rous, Elizabeth Van Eycken WILEY
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